Archive for the ‘Transplants’ Category

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Fecal transplants

April 20, 2011

This is a strange procedure, I know, but some of you have heard of it so I did some digging to see what it’s all about. Fecal transplants–also called fecal bacteriotherapy or human probiotic infusion–are a relatively simple procedure to treat a very dangerous bacteria: C. diff.

This bacteria arises more frequently in hospital situations than in the general public, and affects people who have taken antibiotics. Antibiotic use, while killing bad bacteria, often kill good bacteria as well. C. diff resides in the intestine, and when the good intestinal bacteria are gone, the C. diff has free reign.

The theory with fecal transplants is simple: take stool that has a healthy mix of good bacteria, liquify it, and transplant it into a patient with C. diff. The good bacteria is reestablished in the colon, and the C. diff eventually goes away. Now, as we know, stool doesn’t stay long in the colon, particularly if you have diarrhea caused by C. diff, so I’m not sure if one transplant does the trick or if multiple transplants are needed.

But from case studies, it seems like this is an effective treatment. From all the news stories I read, however, it’s clear that this procedure hasn’t been put through rigorous medical testing yet. Many gastroenterologists won’t perform the procedure because of this. If further tests are done in the future, we’ll find out how useful this procedure really is.

Keep fighting,
~Dennis

News stories that further explain fecal transplants

Fecal transplants to cure Clostridium difficile infection

The Enema of Your Enemy is Your Friend

Same poop, different gut

Scientists Treat Hospital Infection With ‘Fecal Transplant’

Stool transplant is last-ditch method against intestinal superbug C-diff

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Transplant Week: Mason’s story

April 8, 2011

As Transplant Week comes to a close, we have a final video to share with you: the story of 1-year-old Mason’s intestinal transplant. This story is a couple years old, and at the time the family was looking for donations to help pay for the transplant: $60,000. According to the family’s blog, most of that money was raised, so hopefully Mason is in the clear.

Mason was diagnosed with necrotizing enterocolitis or NEC for short. The disease happens in premature infants primarily shortly after birth. The intestinal tissue begins to die, and is life-threatening if untreated. Treatments include stopping regular feeding and switching to IV feedings. Stool and blood work is checked frequently, along with X-rays of the baby’s intestines. Antibiotics are also prescribed for a short period of time until the inflammation is eliminated.

Keep fighting,
~Dennis

For a video of Mason with more explanation of what he’s going through, CLICK HERE. I was unable to embed the video directly from YouTube, so you’ll have to take the extra step of clicking the link yourself.

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Transplant Week: Courtney’s story

April 6, 2011

Transplant Week is half over, and today’s video tells Courtney’s story, a woman who developed a tumor in her intestine during pregnancy. After an early child birth, Courtney had a small bowel transplant performed at the University of Virginia Health System.

According to the University of California San Francisco Medical Center, the one-year survival rate for intestinal transplants is 85%, and 80% of patients can completely transition to a normal diet and activity level.

Transplants come with risks, however. As with all transplants, the body’s immune system conflicts with the transplanted organ’s immune system. Transplant patients are closely monitored in the weeks and months following the transplant to make sure the organ isn’t rejected. To diminish rejection, transplant patients go on immunosuppressant drugs for life.

Keep fighting,
~Dennis

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Transplant Week: Vinny, Jesus and Roberta’s stories

April 5, 2011

Transplant Week continues here at UCVlog. This video, from UCLAHealth, provides three stories from successful transplant recipients. Two children, Vinny and Jesus, both had liver and small bowel transplants. In Jesus’ case, he was born with almost no small intestine, so he went on TPN right away, which eventually damaged his liver. Roberta needed a small bowel and colon transplant after a blood clot blockage the flow of blood in her digestive system.

UCLA Health System has been performing intestinal transplants since 1991. Patients who qualify for transplants are listed with the United Network for Organ Sharing. Typical wait times are 3-12 months, though time varies based on the seriousness of the person’s condition. For a person requiring multiple transplants, like the kids in these stories who need liver and small bowels, each organ is listed separately.

Once an organ is secured, patients generally have just 1-4 hours to arrive at the hospital for the transplantation.

Keep fighting,
~Dennis

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Transplant Week: Margaret’s story

April 4, 2011

It’s Transplant Week here at UCVlog, and we are focusing on all things related to small bowel transplants. This is a major new surgery that’s showing promising results for transplant recipients.

In this video, Margaret Zaprowski, 48, talks about her intestinal and liver transplant. She suffered with Crohn’s disease for decades, and finally had to go on TPN full-time until that destroyed her liver.

Her surgery was performed at the Cleveland Clinic, one of the few hospitals in the world that does intestinal transplants. Crohn’s disease is just one cause of intestinal transplants. For a complete list, click here.

Transplantation comes in three forms: 1) small bowel transplant, in which just the small bowel is replaced; 2) combined liver and small bowel, in which the liver is replaced as well as the small bowel if it was damaged due to excessive TPN use; and 3) multivisceral transplantation, in which the stomach is replaced along with the small intestine.

Keep fighting,
~Dennis

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