Primary sclerosing cholangitis’s connection to ulcerative colitis

April 4, 2012

Here’s a great video from Mayo Clinic discussing primary sclerosing cholangitis, a liver disease associated with ulcerative colitis (in rare cases). It’s an autoimmune disease for which there is currently no effective treatment outside of liver transplant.

When I was first diagnosed with UC, my liver enzymes were out of whack, so we actually tested for PSC and did an MRCP at Mayo Clinic: the doctor in this video was actually my doctor! Then after my surgeries my liver improved dramatically, so now we’re not so sure about PSC (which I’m grateful for). I was told this condition is slow developing: as he says in this video, usually people in their 40s and 50s are diagnosed.

I know very few of you will ever have to worry about PSC. But because it is associated with UC, it is still good to be informed.

Keep fighting,

Question: Have you, or anybody you know, been diagnosed with PSC? What are your experiences with this disease?


  1. if you have psc, please look into the work being done with children at stanford under Dr Cox. Vancomycin is emerging as a very promising treatment for PSC and all of the children on this clinical trial have had their PSC go into remission.

  2. Very informative thanks… I was diagnosed with PSC last October and this has been information has been a great for my own knowledge….

  3. Very informative! Many thanks for posting this.

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